JmjC domain-containing protein-1B; Jumonji domain-containing protein 1B; nuclear protein 5qNCA (KDM3B, JMJD1B, JHDM2B, KIAA1082, C5orf7)

Function

• histone demethylase
• specifically demethylates Lys-9 of histone H3, thus plays a role in histone code
• demethylation of Lys generates formaldehyde & succinate

Cofactor: binds 1 Fe+2 ion per subunit

Structure

• belongs to the JHDM2 histone demethylase family
• contains 1 JmjC domain
• Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate association with nuclear receptors

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• highly expressed in placenta, skeletal muscle, kidney, heart & liver

Genetics

• gene located in 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias & myelodysplasias

More general terms

• JmjC domain-containing protein (JMJD)
• dioxygenase
• histone demethylase
• phosphoprotein
• metalloprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7LBC6.html