protein RMI1 homolog (75 kD BLM-associated protein, BLAP75, FAAP75, RMI1, C9orf76)

Function

• role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells
• promotes TOP3A binding to double Holliday junctions (DHJ) & hence stimulates TOP3A-mediated dissolution
• required for BLM phosphorylation during mitosis
• within the BLM complex, required for BLM & TOP3A stability
• directly interacts with BLM & TOP3A
• may bind DHJ

Compartment

• nucleus
• forms nuclear foci in response to DNA damage

More general terms

• phosphoprotein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H9A7.html