DNA topoisomerase 3-alpha; DNA topoisomerase III alpha (TOP3A, TOP3)

Function

• reduces the number of supercoils in a highly negatively supercoiled DNA
• component of the RMI complex
• ATP-independent breakage of single-stranded DNA, followed by passage & rejoining
• directly interacts with BLM & RMI1

Structure

• belongs to the prokaryotic type I/III topoisomerase family
• contains 1 Toprim domain

Alternative splicing

named isoforms=2

Expression

• high expression is found in testis, heart, skeletal muscle & pancreas

More general terms

• topoisomerase-3
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7156
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7156
• OMIM: https://mirror.omim.org/entry/601243
• UniProt: http://www.uniprot.org/uniprot/Q13472.html