proline-rich AKT1 substrate 1 (40 kD proline-rich AKT substrate) (AKT1S1 PRAS40)

Function

• may play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling
• substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms
• role in survival signaling pathways may be modulated by oxidative stress
• role in nerve growth factor-mediated neuroprotection (putative)
• phosphorylated form interacts with 14-3-3

Compartment

• cytoplasm
• found in the cytosolic fraction of the brain (putative)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest levels of expression in liver & heart

Pathology

• expressed at higher levels in cancer cell lines (e.g. A549 & HeLa) than in normal cell lines (e.g. HEK293)

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96B36.html