cytoskeleton-associated protein 2 (tumor-associated microtubule- associated protein, CTCL tumor antigen se20-10, CKAP2, LB1, TMAP)

Function

• possesses microtubule stabilizing properties
• role in regulating aneuploidy, cell cycling, & cell death (p53/TP53-dependent)
• associates with alpha-tubulin & beta-tubulin (putative)

Compartment

• cytoplasm
• colocalizes with microtubules throughout the cell cycle

Alternative splicing

named isoforms=3

Expression

• abundant in testis, thymus
• barely detectable in liver, prostate & kidney

Pathology

• abundant in tumor derived cell lines
• up-regulated in primary human gastric cancers

More general terms

• microtubule-associated protein (MAP)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WWK9.html