BRCA2 & CDKN1A-interacting protein (protein TOK-1, BCCIP, TOK1)

Function

• may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A
• may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2
• interacts with BRCA2 & CDKN1A

Structure

belongs to the BCP1 family

Compartment

• nucleus
• colocalizes with BRCA2 in discrete nuclear foci

Alternative splicing

named isoforms=3

Expression

• expressed at high levels in testis & skeletal muscle & at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, & spleen
• isoform 1 is expressed throughout the cell cycle
• isoform 2 is expressed following mitosis & peaks in G1/S phase of cell cycle

More general terms

• nuclear protein
• phosphoprotein

Additional terms

• breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein, BRCA2, FACD, FANCD1)
• cyclin-dependent kinase inhibitor 1; p21WAF1/CIP1; p21; CDK-interacting protein 1; melanoma differentiation-associated protein 6; MDA-6 (CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P287.html