protein SDA1 homolog (SDA1 domain-containing protein 1, hSDA, nucleolar protein 130, SDAD1, NUC130)

Function

• required for 60S pre-ribosomal subunits export to the cytoplasm

Structure

belongs to the SDA1 family

Compartment

nucleus, nucleolus

Alternative splicing

named isoforms=2

Expression

• expressed in testis, kidney, spleen, brain & fetal tissues > heart, lung, liver, small intestine, ovary, uterus, mammary gland & placenta
• DAZL & PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation

Polymorphism

• variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NVU7.html