Rho GTPase-activating protein 28 (ARHGAP28, KIAA1314)

Function

• GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 1 Rho-GAP domain

Alternative splicing

named isoforms=4

Expression

• expressed in testis
• sxpressed in kidney & ovary > spleen & skeletal muscle

More general terms

• rho GTPase-activating protein (rho-GAP)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9P2N2.html