PERQ amino acid-rich with GYF domain-containing protein 1 (Grb10-interacting GYF protein 1, PERQ1, CDS2, GIGYF1, PP3360)

Function

• may act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling
• may increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 & SHC1
• interacts with GRB10, transient binding is increased with IGF1 stimulation & leads to recruitment of PERQ1/GRB10 complex to IGF1 receptor
• GYF domain interacts with GRB10

Structure

contains 1 GYF domain

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O75420.html