RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1, REPS1)

Function

• may coordinate cellular actions of activated EGF receptors & Ral-GTPases
• interacts with RAB11FIP2
• interacts with RALBP1, CRK & GRB2
• binding to RALBP1 does not affect its Ral-binding activity
• forms a complex with SH3 domains of CRK & GRB2 which may link it to an EGF-responsive tyrosine kinase
• EGF stimulates phosphorylation on Tyr

Structure

• homodimer
• contains 1 EF-hand domain
• contains 1 EH domain

More general terms

• phosphoprotein
• Ca+2 binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96D71.html