Ras-interacting protein 1 (Rain, RASIP1)

Function

• effector for Golgi-bound HRAS & other Ras-like proteins
• may promote HRAS-mediated transformation
• interacts with Ras family members activated by GTP binding
• interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 & RRAS2

Structure

• contains 1 dilute domain
• contains 1 Ras-associating domain

Compartment

• cytoplasm, perinuclear region, Golgi
• associated with perinuclear vesicles.
• recruited to Golgi stacks by activated HRAS

Expression

• expressed in heart > placenta, pancreas

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5U651.html