protein Shroom3 (Shroom-related protein, hShrmL, SHROOM3, KIAA148, SHRML, MSTP013)

Function

• controls cell shape changes in the neuroepithelium during neural tube closure
• induces apical constriction in epithelial cells by promoting apical accumulation of F-actin & myosin-2, & probably by bundling stress fibers
• induces apicobasal cell elongation by redistributing gamma-tubulin & directing assembly of apicobasal microtubule arrays
• interacts with F-actin

Structure

• belongs to the shroom family
• contains 1 ASD1 domain ASD1 domain mediates F-actin binding
• contains 1 ASD2 domain ASD2 domain is required for apical constriction induction
• contains 1 PDZ domain (DHR domain)

Compartment

• cell junction, adherens junction
• cytoplasm, cytoskeleton
• colocalizes with F-actin in stress fibers & adherens junctions

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein
• protein Shroom

Database

• OMIM: https://mirror.omim.org/entry/604570
• UniProt: http://www.uniprot.org/uniprot/Q8TF72.html