AP1 subunit gamma-binding protein 1; gamma-synergin (AP1GBP1, SYNG, SYNRG)

Function

• role in endocytosis &/or membrane trafficking at trans-Golgi
• links adapter protein complex AP-1 to other proteins (putative)
• interacts with SCAMP1 via its EH-domain
• interacts with GGA1, GGA2 & GGA3
• interacts with the AP1G1 & AP1G2 subunits of adapter protein complexes AP-1

Structure

• contains 1 EH domain
• DFXDF motifs mediate the interaction with gamma- appendage subunits AP1G1 & AP1G2

Compartment

• cytoplasm, trans-Golgi, peripheral membrane protein
• associates with membranes via adapter protein complex AP-1
• colocalizes with AP1G1

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607291
• UniProt: http://www.uniprot.org/uniprot/Q9UMZ2.html