F-box only protein-43 (endogenous meiotic inhibitor 2, FBXO43, EMI2)

Function

• required to establish & maintain arrest of oocytes at 2nd meiotic metaphase until fertilization
• inhibits anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase
• promotes ubiquitination & degradation of undetermined phosphoproteins
• ubiquitin conjugation, 3rd step
• component of SCF complex
• interacts with CDC20 (putative).
• phosphorylated on Ser-76, Thr-234 & Ser-334 in response to Ca+2 - prerequisite for ubiquitination & proteasomal degradation

Structure

• contains 1 F-box domain
• contains 1 IBR-type zinc finger

More general terms

• F-box only protein
• phosphoprotein
• zinc finger protein

Component of

• SCF-type E3 ligase complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q4G163.html