protein numb homolog (h-Numb, protein S171, NUMB)

Function

• control of cell fate decisions during development (putative)
• interacts with EPS15, LNX & NOTCH1
• interacts with DUOXA1 (putative)
• ubiquitinated
  • isoform 1 & 2 are ubiquitinated by LNX
  • mediated by SIAH
  • subsequent proteasomal degradation

Structure

• contains 1 PID domain

Compartment

membrane

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603728
• UniProt: http://www.uniprot.org/uniprot/P49757.html