tensin-4 (C-terminal tensin-like protein, TNS4, CTEN, PP14434)

Function

• cell migration (putative)
• cartilage development (putative)
• links signal transduction pathways to cytoskeleton
• may promote apoptosis, via cleavage by caspase-3
• binds to actin filaments
• interacts with phosphotyrosine-containing protein
• tyrosine phosphorylated
• proteolytically cleaved by caspase-3 during apoptosis

Structure

• contains 1 phosphatase tensin-type domain.
• contains 1 SH2 domain

Compartment

cell junction, focal adhesion

Expression

expressed in prostate, placenta

Pathology

• down regulated in prostate cancer

More general terms

• phosphoprotein
• tensin

Additional terms

• tensin-1 (TNS1 TNS)

Database

• OMIM: https://mirror.omim.org/entry/608385
• UniProt: http://www.uniprot.org/uniprot/Q8IZW8.html