vesicle-associated membrane protein 4 (VAMP-4, VAMP4)

Function

• involved in pathway removes an inhibitor* of Ca+2-triggered exocytosis during maturation of secretory granules
• component of sorting pathway critical for remodeling the secretory response of granule

* probably synaptotagmin-4

Structure

• belongs to the synaptobrevin family
• contains 1 v-SNARE coiled-coil homology domain Golgi, trans-Golgi network & newly formed immature secretory granules, not found on the mature secretory organelles

Alternative splicing

named isoforms=2

More general terms

• SNARE protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606909
• UniProt: http://www.uniprot.org/uniprot/O75379.html