transcriptional-regulating factor 1 (transcriptional-regulating protein 132, zinc finger transcription factor TReP-132, zinc finger protein rapa, breast cancer anti-estrogen resistance 2, TRERF1, BCAR2, RAPA, TREP132)

Function

• activates transcription of CYP11A1
• interaction with CREBBP & EP300 results in a synergistic transcriptional activation of CYP11A1
• interacts with CREBBP & EP300
• contains 3 C2H2-type zinc fingers
  • contains 1 ELM2 domain
  • contains 1 Myb DNA-binding domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• expressed in thymus, testis, adrenal cortex > a drenal medulla, thyroid, stomach
• expressed in steroidogenic JEG-3 & MCF-7 cells > non-steroidogenic HepG2 & HK293 cells

More general terms

• DNA-binding protein
• phosphoprotein
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96PN7.html