latrophilin-1 (Ca+2-independent alpha-latrotoxin receptor 1, lectomedin-2, LPHN1, KIAA0821, LEC2)

Function

• high affinity Ca+2-independent receptor for alpha-latrotoxin
• regulation of exocytosis (putative)
• proteolytically cleaved into 2 subunits
  • a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85)
  • proteolytic processing takes place in the Golgi apparatus
• interacts with syntaxin & with proteins of the SHANK family via the PDZ domain (putative)
• extracellular domain coupled to single transmembrane domian sufficient for full responsiveness to alpha-latrotoxin

Alternative splicing

named isoforms=2

More general terms

• latrophilin
• phosphoprotein

Additional terms

• alpha latrotoxin

Database

• UniProt: http://www.uniprot.org/uniprot/O94910.html