embryonal Fyn-associated substrate (EFS)
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Function
- docking protein
- coordinating role for tyrosine-kinase-based signaling related to cell adhesion
- activator of SRC & a downstream effector
- interacts with the SH3 domain of FYN
- interacts with CRK, SRC, YES
- SH3 domain interacts with focal adhesion kinase 1
- SH2-binding sites putatively bind CRK, NCK & ABL SH2 domains
- phosphorylated on multiple tyrosine residues
- phosphorylated on tyrosines by FYN & SRC
Alternative splicing
named isoforms=2
Expression
expressed in lung, placenta