nucleolar & coiled-body phosphoprotein 1; 140 kD nucleolar phosphoprotein; Nopp140; hepatitis C virus NS5A-transactivated protein 13; HCV NS5A-transactivated protein 13; nucleolar 130 kD protein; nucleolar phosphoprotein p130 (NOLC1, KIAA0035, NS5ATP13)

Function

• related to nucleologenesis
• may play a role in maintenance of the fundamental structure of the fibrillar center & dense fibrillar component in the nucleolus
• has intrinsic GTPase & ATPase activities
• may play an important role in transcription catalyzed by RNA polymerase 1
• undergoes rapid & massive phosphorylation/dephosphorylation cycles on CK2 & PKC sites
• CDK1 kinase may phosphorylate NOLC1 in M-phase
• interacts with RNA polymerase 1 194 kD subunit (RPA194) & with casein kinase-2

Structure

contains 1 LisH domain

Compartment

• nucleus, nucleolus, cytoplasm
• shuttles between the nucleolus & the cytoplasm
• at telophase, it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase

Alternative splicing

named isoforms=3; alpha, beta

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9221
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9221
• OMIM: https://mirror.omim.org/entry/602394
• UniProt: http://www.uniprot.org/uniprot/Q14978.html