alpha-endosulfine; ARPP-19e (ENSA)

Function

• endogenous ligand for sulfonylurea receptor
• inhibits ATP-dependent K+ channel currents
• stimulates insulin secretion
• phosphorylated by protein kinase A

Structure

belongs to the endosulfine family

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=8

Expression

• widely expressed
• high expression in skeletal muscle & brain
• lower expression in pancreas

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2029
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2029
• OMIM: https://mirror.omim.org/entry/603061
• UniProt: http://www.uniprot.org/uniprot/O43768.html