ATP-binding cassette sub-family F member 1; ATP-binding cassette 50; TNF-alpha-stimulated ABC protein (ABCF1, ABC50)

Function

• mRNA translation
• interacts with eukaryotic initiation factor 2 (eIF2)
• associates with the ribosomes
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the ABC transporter family, EF3 subfamily
• contains 2 ABC transporter domains

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• induced by TNF (in cultured synoviocytes)

More general terms

• ATP-binding cassette sub-family F (ABC transporter-F, ABCF)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23
• OMIM: https://mirror.omim.org/entry/603429
• UniProt: http://www.uniprot.org/uniprot/Q8NE71.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23