muscarinic M2 receptor; muscarinic acetylcholine receptor M2 (CHRM2)
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Function
- muscarinic acetylcholine receptor
- primary transducing effect is inhibition of adenylate cyclase (via Gi protein)
- in the CNS, CHRM2 is a presynaptic autoreceptor which down-regulates release of acetylcholine from presynaptic terminals
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Polymorphism
- genetic variations in CHRM2 can influence susceptibility to alcoholism
- genetic variations in CHRM2 can influence susceptibility to major depressive disorder
More general terms
References
- ↑ Conkilin et al PNAS 85:8698 (1988)
- ↑ Role of cholinergic therapy in treatment of Alzheimer's disease & other dementias, Farlow, M et al, 2001
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1129
- ↑ OMIM https://mirror.omim.org/entry/103780
Database
- UniProt: http://www.uniprot.org/uniprot/P08172.html
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1129
- OMIM: https://mirror.omim.org/entry/103780
- OMIM: https://mirror.omim.org/entry/118493
- OMIM: https://mirror.omim.org/entry/608516
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1129