ATP-dependent RNA helicase DDX23; 100 kD U5 snRNP-specific protein; DEAD box protein 23; PRP28 homolog; U5-100kD (DDX23)
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Function
- role in pre-mRNA splicing (putative)
- component of U5 & U5.4/6 snRNP complexes
- in vitro phosphorylated by CLK1 & U1 snRNP-associated protein kinase
- identified in the spliceosome C complex
- interacts with ERBB4
Structure
- belongs to the DEAD box helicase family, DDX23/PRP28 subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain