PI-3-kinase p85 subunit
Jump to navigation
Jump to search
Function
- binds to activated (phosphorylated) tyrosine kinases, through its SH2 domain
- acts as an adapter, mediating association of the p110 catalytic unit to the plasma membrane
Structure
More general terms
More specific terms
- phosphatidylinositol 3 kinase regulatory subunit beta (Ptdins-3-kinase p85-beta, PIK3R2)
- PI-3-kinase p85 alpha
- PI-3-kinase p85 gamma (PIK3R3)
Component of
References
- ↑ Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846320
- ↑ Saltiel AR. The paradoxical regulation of protein phosphorylation in insulin action. FASEB J. 1994 Oct;8(13):1034-40. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7926368
- ↑ Lavin MF, Khanna KK, Beamish H, Spring K, Watters D, Shiloh Y. Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. Trends Biochem Sci. 1995 Oct;20(10):382-3. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533147 (S608)