phosphatidylinositol 3 kinase regulatory subunit beta (Ptdins-3-kinase p85-beta, PIK3R2)

Function

• binds to activated (phosphorylated) tyrosine kinases, through its SH2 domain, & acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane
• heterodimer of a p110 (catalytic) & a p85 (regulatory) subunits

Structure

• belongs to the PI3K p85 subunit family
• contains 1 Rho-GAP domain
• contains 2 SH2 domains
• contains 1 SH3 domain

More general terms

• PI-3-kinase p85 subunit

Database

• UniProt: http://www.uniprot.org/uniprot/O00459.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5296
• OMIM: https://mirror.omim.org/entry/603157
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5296