DNA-3-methyladenine-glycosidase (3-methyladenine DNA glycosylase, 3-alkyladenine DNA glycosylase, N-methylpurine-DNA glycosylase, MPG)

Function

• hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, & 7-methylguanine from damaged DNA polymer formed by alkylation lesions
• binds MBD1
• hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine & 7-methyladenine

Structure

belongs to the DNA glycosylase MPG family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=3

Genetics

Gene locus: 16p13.3

More general terms

• DNA glycosylase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P29372.html
• OMIM: https://mirror.omim.org/entry/156565
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4350