AMP-activated protein kinase gamma-2 subunit (AMPK gamma-2 chain, PRKAG2, H91620p)

Function

• regulatory subunit of AMPK
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the 5'-AMP-activated protein kinase gamma subunit family
• contains 4 CBS domains

Alternative splicing

named isoforms=3

Expression

• isoform B is ubiquitously expressed except in liver & thymus highest level is detected in heart abundant expression in placenta & testis

Pathology

• defects in PRKAG2 are a cause of
  • Wolff-Parkinson-White syndrome
  • familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome
  • phosphorylase kinase deficiency of heart

More general terms

• AMP-activated protein kinase-gamma subunit
• phosphoprotein

Additional terms

• Wolff-Parkinson-White (WPW) syndrome

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5142
• OMIM: https://mirror.omim.org/entry/194200
• OMIM: https://mirror.omim.org/entry/261740
• OMIM: https://mirror.omim.org/entry/600858
• OMIM: https://mirror.omim.org/entry/602743
• UniProt: http://www.uniprot.org/uniprot/Q9UGJ0.html