activation-induced cytidine deaminase (cytidine aminohydrolase, AICDA, AID)

Function

• RNA-editing deaminase involved in somatic hypermutation, gene conversion, & class-switch recombination
• required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses

cytidine + H2O <--> uridine + NH3

Cofactor: Zn+2

Structure

• belongs to the cytidine & deoxycytidylate deaminase family

Expression

• strongly expressed in lymph nodes & tonsils

Pathology

• defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2

More general terms

• metalloprotein
• nucleoside deaminase

Component of

• activation induced cytidine deaminase/ibuprofen/pseudoephedrine
• activation induced cytidine deaminase/benzocaine/cetylpyridinium

Database

• OMIM: https://mirror.omim.org/entry/605257
• OMIM: https://mirror.omim.org/entry/605258
• UniProt: http://www.uniprot.org/uniprot/Q9GZX7.html