apoptosis-inducing factor-like protein (AIFL, AIFM3)

Function

• induces apoptosis through a caspase dependent pathway
  • the Rieske domain induces apoptosis
• reduces mitochondrial membrane potential

Structure

• belongs to the FAD-dependent oxidoreductase family
• contains 1 Rieske domain

Compartment

• mitochondrion
• does not translocate to the nucleus upon induction of apoptosis

Alternative splicing

named isoforms=4

Expression

• ubiquitous
• expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland, tongue (at protein level)

More general terms

• oxidoreductase
• metalloprotein
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96NN9.html