serine/threonine protein phosphatase with EF-hands 2; PPEF-2 (PPEF2)

Function

• may play a role in phototransduction
• may dephosphorylate photoactivated rhodopsin
• may function as a Ca+2 sensing regulator of ionic currents, energy production or synaptic transmission
• activated by Ca+2 (putative)

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

Structure

• belongs to the PPP phosphatase family
• contains 3 EF-hand domains
• contains 1 IQ domain

Compartment

• cytoplasm (probable)
• cell projection, cilium
• photoreceptor outer segment
• photoreceptor inner segment
• localized to photoreceptors
• PPEF-2(L) is at least 2 fold more abundant in rod inner segments than in the rod outer segments

Alternative splicing

• named isoforms=2; PPEF-2(L), PPEF-2(S)

Expression

retinal specific (probable)

More general terms

• serine/threonine phosphatase
• metalloprotein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5470
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5470
• OMIM: https://mirror.omim.org/entry/602256
• UniProt: http://www.uniprot.org/uniprot/O14830.html