serine/threonine protein phosphatase with EF-hands 1; PPEF-1; protein phosphatase with EF Ca+2-binding domain; PPEF; serine/threonine protein phosphatase 7; PP7 (PPEF1, PPEF, PPP7C)

Function

• may have a role in the recovery or adaptation response of photoreceptors
• may have a role in development
• activated by Ca+2

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)
• Mg+2 (putative)

Kinetic parameters:

• pH dependence: optimum pH is 8.0

Structure

• belongs to the PPP phosphatase family
• contains 3 EF-hand domains
• contains 1 IQ domain

Alternative splicing

named isoforms=5

Expression

• detected in retina & retinal derived Y-79 retinoblastoma cells
• also found in fetal brain

More general terms

• serine/threonine phosphatase
• metalloprotein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5475
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5475
• OMIM: https://mirror.omim.org/entry/300109
• UniProt: http://www.uniprot.org/uniprot/O14829.html