sciellin (SCEL)

Function

• may function in the assembly or regulation of proteins in the cornified envelope
• the LIM domain may be involved in homotypic or heterotypic associations & may function to localize sciellin to the cornified envelope

Structure

contains 1 LIM Zn+2-binding domain

Compartment

• cytoplasm, membrane
• may become cross-linked to membrane proteins by transglutaminase

Alternative splicing

named isoforms=2

Expression

• highly expressed in esophagus
• also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum & stratum granulosum, hair follicle & nail

More general terms

• metalloprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8796
• OMIM: https://mirror.omim.org/entry/604112
• UniProt: http://www.uniprot.org/uniprot/O95171.html