carboxypeptidase N catalytic chain (CPN, carboxypeptidase N polypeptide 1, carboxypeptidase N small subunit, Lysine carboxypeptidase, arginine carboxypeptidase, kininase-1, serum carboxypeptidase N, SCPN, anaphylatoxin inactivator, plasma carboxypeptidase B, CPN1, ACBP)

Function

• catalytic subunit of carboxypeptidase N
• protective against potent vasoactive & inflammatory peptides containing C-terminal Arg or Lys (kinins or anaphylatoxins) which are released into the circulation

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

belongs to the peptidase M14 family

Compartment

secreted, extracellular space

Expression

plasma

More general terms

• protein subunit
• metalloprotein

Component of

• carboxypeptidase-N, plasma carboxypeptidase-B, kininase-1, anaphylatoxin inactivator or arginine carboxypeptidase

Database

• UniProt: http://www.uniprot.org/uniprot/P15169.html
• OMIM: https://mirror.omim.org/entry/212070
• OMIM: https://mirror.omim.org/entry/603103
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1369
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1369