interferon-induced guanylate-binding protein 5; GBP-TA antigen; GTP-binding protein 5; GBP-5; guanine nucleotide-binding protein 5 (GBP5)

Function

• stimulates the NLRP3 inflammasome assembly upon bacterial challenge
• homotetramer when interacting with NLRP3 (putative)
• homodimerizes upon GTP-binding, dimerization is required for the second hydrolysis step from GDP to GMP
• can also heterodimerize with other members of the family, homotetramer when interacting with NLRP3

Structure

belongs to the GBP family

Compartment

cell membrane, lipid-anchor, cytoplasmic side

Alternative splicing

• named isoforms=2
• antigenic tumor-specific truncated splice form

Expression

• induced by interferon gamma during macrophage activation

More general terms

• prenyl protein

Additional terms

• mitochondrial ribosome-associated GTPase 2; GTP-binding protein 5; protein obg homolog 1; ObgH1 (MTG2, GTPBP5, OBGH1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=115362
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:115362
• OMIM: https://mirror.omim.org/entry/611467
• UniProt: http://www.uniprot.org/uniprot/Q96PP8.html