G protein-coupled receptor kinase-7 (GRK7, GPRK7)

Function

• phosphorylates cone opsins thereby initiating their deactivation

ATP + [G-protein-coupled receptor]
            <-->
ADP + [G-protein-coupled receptor] phosphate

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thrprotein kinase family, GPRK subfamily
• contains 1 AGC-kin ase C-terminal domain
• contains 1 protein kinase domain
• contains 1 RGS domain

Compartment

membrane; lipid-anchor

Expression

Retina, cones & rods

More general terms

• G protein-coupled receptor kinase
• prenyl protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1318
• OMIM: https://mirror.omim.org/entry/605069
• OMIM: https://mirror.omim.org/entry/606987
• UniProt: http://www.uniprot.org/uniprot/Q8WTQ7.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2872