methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3, MSRB3)

Function

• catalyzes the reduction of free & protein-bound methionine sulfoxide to methionine

L-methionine + oxidized thioredoxin <--> L-methionine R-oxide + reduced thioredoxin

Cofactor: binds 1 Zn+2 per subunit

Structure

• monomer
• belongs to the msrB Met sulfoxide reductase family
• has a signal peptide

Compartment

• isoform 1: mitochondrion
• isoform 2: endoplasmic reticulum

Alternative splicing

named isoforms=2

Expression

• detected in eye lens, colon, bone marrow, cerebellum, small intestine, heart, kidney & spinal cord

More general terms

• oxidoreductase
• mitochondrial protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2538
• UniProt: http://www.uniprot.org/uniprot/Q8IXL7.html