mitochondrial peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; peptide Met(O) reductase; protein-methionine-S-oxide reductase; PMSR (MSRA)

Function

• role as a repair enzyme for proteins that have been inactivated by oxidation
• catalyzes reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin

Structure

• belongs to the MsrA Met sulfoxide reductase family

Compartment

• isoform 1: mitochondrion
• isoform 2: cytoplasm
• isoform 3: cytoplasm, nucleus

Alternative splicing

• isoform 1 produced by alternative splicing

Alternative promoter usage

• isoforms 2 & 3 produced by alternative promoter usage

Expression

• ubiquitous
• expressed in adult kidney & cerebellum > liver, heart ventricles, bone marrow & hippocampus

More general terms

• oxidoreductase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4482
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4482
• OMIM: https://mirror.omim.org/entry/601250
• UniProt: http://www.uniprot.org/uniprot/Q9UJ68.html