methionine aminopeptidase 1D, mitochondrial (MAP1D, METAP1D)

Function

• removes the amino-terminal methionine from nascent proteins (putative)
• release of N-terminal amino acids, preferentially methionine, from peptides & arylamides

Structure

belongs to the peptidase M24A family

Compartment

mitochondria

Pathology

• may play a role in colon tumorigenesis
• overexpressed in colon cancer cell lines & colon tumors compared to normal tissues (at protein level)

Notes

• uncertain whether Met-1 or a Met upstream of this sequence is the initiator

More general terms

• methionyl aminopeptidase
• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UB28.html