mitochondrial dimethyladenosine transferase 2 (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, mitochondrial 12S rRNA dimethylase 2, mitochondrial transcription factor B2, mtTFB2, h-mtTFB2, h-mtTFB, hTFB2M, hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, TFB2M, NS5ATP5)

Function

• S-adenosyl-L-methionine-dependent methyltransferase
• specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop
• required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT & TFAM
• stimulates transcription independently of methyltransferase activity
• compared to TFB1M
  • activates transcription of mitochondrial DNA more efficiently
  • has less methyltransferase activity
• interacts with mitochondrial RNA polymerase POLRMT.
• interacts with TFAM

Structure

• belongs to the rRNA adenine N(6)-methyltransferase family. KsgA subfamily

Compartment

mitochondrion

Expression

• ubiquitously expressed
• induced by the nuclear respiratory factors NRF1 & NRF2/GABPB2 & PGC-1 coactivators

More general terms

• methyltransferase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/607055
• UniProt: http://www.uniprot.org/uniprot/Q9H5Q4.html