transcription factor A, mitochondrial; mtTFA; mitochondrial transcription factor 1; MtTF1; transcription factor 6; TCF-6; transcription factor 6-like 2 (TFAM, TCF6, TCF6L2)

Function

• role in mitochondrial transcription regulation
• required for accurate & efficient promoter recognition by the mitochondrial RNA polymerase
• activates transcription by binding immediately upstream of transcriptional start sites
• able to unwind & bend DNA
• interacts with TFB1M & TFB2M

Structure

contains 2 HMG box DNA-binding domains

Compartment

mitochondrial matrix

More general terms

• mitochondrial protein
• transcription factor (TF)
• DNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7019
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7019
• OMIM: https://mirror.omim.org/entry/600438
• UniProt: http://www.uniprot.org/uniprot/Q00059.html