peptidyl-tRNA hydrolase 2, mitochondrial (PTH-2, Bcl-2 inhibitor of transcription 1, PTRH2, BIT1, PTH2, CGI-147)

Function

• natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis
• promotes caspase-independent apoptosis by regulating function of 2 transcriptional regulators, AES & TLE1

N-substituted aminoacyl-tRNA + H2O <--> N-substituted amino acid + tRNA

Structure

• monomer
• belongs to the PTH2 family

Compartment

mitochondrion

More general terms

• hydrolase
• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/608625
• UniProt: http://www.uniprot.org/uniprot/Q9Y3E5.html