succinyl-CoA:3-ketoacid-coenzyme A transferase 2 (testis-specific succinyl CoA:3-oxoacid CoA-transferase, SCOT-t, OXCT2)

Function

• key enzyme for ketone body catabolism
• transfers CoA moiety from succinate to acetoacetate
• formation of the enzyme-CoA intermediate proceeds via an unstable anhydride formed between the carboxylate groups of the enzyme & substrate
• ketolysis, 1st step

succinyl-CoA + 3-oxo acid <--> succinate + 3-oxoacyl-CoA

Structure

homodimer

Compartment

mitochondrion

Expression

testis specific

More general terms

• transferase
• mitochondrial protein
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BYC2.html