L-threonine 3-dehydrogenase, mitochondrial (TDH)

Structure

belongs to the sugar epimerase family

Compartment

mitochondria (putative)

Alternative splicing

named isoforms=3

Expression

• expressed in all tissues examined
• detected in most cell types,
• not observed in endothelial cells, glioma cell lines & some leukemia cell lines

Notes

• may be expressed pseudogene encoding non-functional truncated proteins that are unable to make appropriate contacts with substrates, L-threonine & NAD+.
• although all exons expected to encode a functional L-threonine 3-dehydrogenase of 369 residues are present in the human genome, all transcripts described encode truncated proteins that result from mutations within the gene causing the loss of acceptor splice site preceding exon 4 & exon 6

More general terms

• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IZJ6.html