mitochondrial 18 kD protein (MTP18, MTFP1)

Function

• essential for cell viability
• role in maintaining integrity of mitochondrial network
• loss-of-function induces the release of cytochrome c, which activates the caspase cascade & leads to apoptosis

Structure

belongs to the MTP18 family

Compartment

mitochondria

Expression

• expression regulated by the phosphatidylinositol-3-kinase pathway

More general terms

• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UDX5.html