mimitin; Myc-induced mitochondrial protein; B17.2-like; B17.2L; NDUFA12-like protein (MMTN, NDUFA12L, NDUFAF2)

Function

• acts as a molecular chaperone for mitochondrial complex 1 assembly
• direct transcriptional target of Myc

Structure

belongs to the complex 1 NDUFA12 subunit family

Compartment

mitochondrion

Expression

• highly expressed in ESCC cells
• also expressed in heart, skeletal muscle, liver, & in fibroblasts
• induced by Myc

Pathology

• defects in NDUFA12L are a cause of mitochondrial respiratory chain complex 1 deficiency

More general terms

• mitochondrial protein

Database

• OMIM: https://mirror.omim.org/entry/252010
• UniProt: http://www.uniprot.org/uniprot/Q8N183.html