mitochondrial import inner membrane translocase subunit TIM16; mitochondria-associated granulocyte macrophage CSF-signaling molecule; presequence translocated-associated motor subunit PAM16 (PAM16, MAGMAS, TIM16, TIMM16, CGI-136)

Function

• regulates ATP-dependent protein translocation into the mitochondrial matrix
• inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity
• probable component of the PAM complex
• interacts with DNAJC19
• associates with the TIM23 complex

Structure

• the J-like region, although related to the J domain does not have co-chaperone activity (putative)
• belongs to the TIM16/PAM16 family

Compartment

• mitochondrial inner membrane
• peripheral membrane, matrix side

Expression

• ubiquitously expressed
• induced by CSF2/GM-CSF

More general terms

• mitochondrial protein

Component of

• PAM complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51025
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51025
• OMIM: https://mirror.omim.org/entry/614336
• UniProt: http://www.uniprot.org/uniprot/Q9Y3D7.html