A-kinase anchor protein 10, mitochondrial; AKAP-10; dual specificity A kinase-anchoring protein 2; D-AKAP-2; protein kinase A-anchoring protein 10; PRKA10 (AKAP10)

Function

• differentially targeted protein that binds to type I & II regulatory subunits of protein kinase A & anchors them to the mitochondria or the plasma membrane
• BAD, a proapoptotic member, may be phosphorylated & inactivated by mitochondria-anchored PKA
• may act as an adapter for assembling multiprotein complexes
• may interact with G-alpha proteins (via RGS domain), linking signaling with downstream kinases

Structure

• PKA-RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the PKA-R-subunit dimer
• contains 2 RGS domains

Compartment

• mitochondria, membrane, cytoplasm
• predominantly mitochondrial but also membrane associated & cytoplasmic

More general terms

• A-kinase anchor protein
• mitochondrial protein
• phosphoprotein

Additional terms

• protein kinase A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11216
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11216
• OMIM: https://mirror.omim.org/entry/604694
• UniProt: http://www.uniprot.org/uniprot/O43572.html