thioredoxin-dependent peroxide reductase, mitochondrial; peroxiredoxin-3; PRX III; antioxidant protein 1; AOP-1; protein MER5 homolog; HBC189 (PRDX3, AOP1)

Function

• role in redox regulation of the cell
• protects radical-sensitive enzymes from oxidative damage by a radical-generating system
• acts synergistically with MAP3K13 to regulate activation of NF-kappa-B in the cytosol
• disulfide-linked, upon oxidation
• binds MAP3K13
• the active site is the redox-active Cys-108 oxidized to Cys-SOH
• Cys-SOH rapidly reacts with Cys-229-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation
• the enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
• irreversibly inactivated by overoxidation of Cys-108 (to Cys-SO(3)H) upon oxidative stress

Structure

• dodecameric ring assembled from homodimeric units
• the rings have an approximate diameter of 150 A & a central hole of 70 A. 3-5% of the rings are interlocked by pairs
• belongs to the ahpC/TSA family
• contains 1 thioredoxin domain

Compartment

mitochondria

More general terms

• mitochondrial protein

Database

• UniProt: http://www.uniprot.org/uniprot/P30048.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10935
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10935
• OMIM: https://mirror.omim.org/entry/604769